Mantle cell lymphoma with multiple lymphomatous polyposis. Lymphomatous polyposis lp is a distinct clinicopathologic condition. Multiple lymphomatous polyposis originates from the mantle zone of the lymphoma follicle and is considered to be a mantle cell lymphoma, which is a relatively aggressive type of bcell nonhodgkins lymphoma. Extensive colorectal lymphomatous polyposis complicated by. Multiple lymphomatous polyposis mlp is an uncommon type of gastrointestinal lymphoma.
Multiple lynphomatous polyposis is a type of appearance of mantle cell lymphoma. A master limited partnership allows limited partners to buy and sell units of the. Primary gastrointestinal tcell lymphoma resembling multiple. Multiple polypoid masses of the distal ileum were identified in the right hemicolectomy. Complete response in a patient with colonic mantle. Multiple biopsies of the complete gi tract presented diffuse infiltration of monotonous smalltomedium sized, lymphoid cells. Mantlecell lymphoma multiple lymphomatous polyposis of the. Biopsy was performed again to confirm the diagnosis of colonic mcl. Gi polyposis occurs in up to 10% of cases, including conditions such as multiple lymphomatous polyposis mlp and immunoproliferative. Multiple lymphomatous polyposis was detected by endoscopy.
We report the first case of diffuse large bcell lymphoma presenting as multiple lymphomatous polyposis of the gi tract in a 49yearold patient with hiv and describe the clinicopathologic features. Multiple lymphomatous polyposis mlp is an uncom mon type of primary non hodgkin gastrointestinal gi b cell lymphoma characterized by the presence of. Lymphomatous definition of lymphomatous by medical. Ileocecal resection was performed on immunohistochemical examination, the. From 1984 to 1995, 31 patients were enrolled prospectively. Multiple lymphomatous polyposis with diffuse involvement of. An extensive histopathologic and immunohistochemical study of 12 cases.
The differential diagnoses of multiple lymphomatous polyposis includes adenomatous polyps, with or without carcinomatous degeneration, familial polyposis and syndromes of peutzjeghers and nodular. Master limited partnership master limited partnership a limited partnership with ownership units that may be traded on an exchange. Alkpositive anaplastic large cell lymphoma presenting. Multiple lymphomatous polyposis of the gastrointestinal tract multiple lymphomatous polyposis of the gastroin testinal tract has been reported rarely. Multiple lymphomatous polyposis of the intestine with. Exhaustive staging and immunohistochemical analysis were performed. One case had multiple relapses despite treatment and died after 58 months. Lymphomatous definition of lymphomatous by the free. Mantle cell lymphoma with multiple lymphomatous polyposis and.
Colonoscopy with multiple polypoid lesions ranging from 0. Multiple lymphomatous polyposis is a rare type of gastrointestinal lymphoma that extensively infiltrates the intestine. A rare case of multiple lymphomatous polyposis with widespread. Multiple lymphomatous polyposis lp is a rare entity, characterized by multiple polypoid tumors involving several segments of the gastrointestinal tract. Small bowel followup examination with barium shows multiple smooth and round. A micronodular pattern of splenic involvement are seen in both mantle cell lymphoma and splenic marginal zone lymphoma villous cells in pb may be seen in mantle cell lymphoma mantle cell lymphoma expresses cd5 and cyclin d1. Diffuse large bcell lymphoma presenting as multiple. Patients range from 37 to 83 years of age, with a male predominance. Morphological and immunohistochemical studies are essential for diagnosis of mlp. Meeting abstract open access multiple lymphomatous.
Multiple lymphomatous polyposis mlp is an uncommon disease that is regarded as the gastrointestinal form of mcl. The gastrointestinal tract is the predominant site of appearance of extranodal nonhodgkin lymphomas. Extranodal involvement of the gi tract is a wellrecognized entity of mantle cell lymphoma. We report two rare cases of multiple lymphomatous polyposis of the gastrointestinal tract. Ileocecal resection was performed on immunohistochemical. Multiple lymphomatous polyposis article about multiple. Multiple lymphomatous polyposis is a distinctive and particularly rare clinical type of malignant gastrointestinal lymphoma, which is classified as bcell centrocytic nonhodgkins lymphoma. Multiple lymphomatous polyposis is thought to represent mantle cell lymphoma of the gi tract. A case of mantle cell lymphoma mcl associated with multiple lymphomatous polyposis mlp is reported is a 62yearold woman, with special reference to the patients clinical features and response to treatment. Pdf colonic mantle cell lymphoma with multiple lymphomatous. A rare case of multiple lymphomatous polyposis due to mantle cell lymphoma is reported in a 34yearold man.
Pdf mantle cell lymphoma presenting as multiple lymphomatous. Mantlecell lymphoma multiple lymphomatous polyposis of. In fact tumor cells, typically, express cd20 or cd5 and cyclin d1 markers in these conditions. Pdf multiple lymphomatous polyposis ibrahim arslan. Lymphomatous definition of lymphomatous by the free dictionary. A limited partnership consists of a general partner, who manages the venture, and limited partners, who simply provide capital. Multiple lymphomatous polyposis of the gastrointestinal.
These findings confirmed the diagnosis of multiple lymphomatous polyposis of the gastrointestinal tract, which was first proposed by cornes in 1961. Multiple lymphomatous polyposis can present with diverse clinical symptoms including abdominal pain, diarrhea, bleeding, proteinlosing. Multiple lymphomatous polyposis of the gastrointestinal tract department of pathology and department of gastroenterological surgery, hospital do servidor publico estadual, sao paulo, brazil context. In this large retrospective series of 12 patients with lp, histologic and immunohistochemical features were investigated from patients with multiple biopsy samples from each site. Most cases occur at multiple sites from oesophagus to rectum. Pdf multiple lymphomatous polyposis mustafa benekli. Gastrointestinal multiple lymphomatous polyposis is a rare type of malignant lymphoma that has aggressive biological behavior, early. Arch pathol lab medvol 127, august 2003 multiple lymphomatous polyposisremestroche et al 1029 figure 1. Mantlecell lymphoma multiple lymphomatous polyposis. Multiple lymphomatous polyposis of the gastrointestinal tract can be associated with the bcell lymphoma variant, mantle cell lymphoma, with most cases having been described in patients who are more than 50 yearsofage. Multiple lymphomatous diverticulosis and comorbid chronic.
Multiple lymphomatous polyposis with diffuse involvement. The ileocecal region is the commonest site involved. Methods a 78 years old patient was admitted to our department of. In this large retrospective series of 12 pa tients with lp, histologic and immunohistochemical fea tures. Mantle cell lymphoma presenting as multiple lymphomatous. Multiple lymphomatous polyposis is a distinctive and rare type of malignant gi lymphoma. Approximately 60 cases of mlp have been reported so far. Cell proliferation may be nodular or diffuse with a mixed nodular pattern. Multiple lymphomatous polyposis is a specific type of lymphomas. Multiple lymphomatous polyposis mlp is an uncom mon type of primary nonhodgkin gastrointestinal gi b cell lymphoma characterized by the presence of. The lymphoma is of centrocytic type and exhibits a nodular pattern of. This is a rare gastrointestinal nonhodgkin lymphoma forming numerous polyps.
There were multiple widespread polypoid lesions in the entire gastrointestinal tract, with ileocecal masses. Only 4% of intestinal lymphomas result in polyposis. Multiple lymphomatous polyposis is an uncommon but distinctive form of gastrointestinal lymphoma. Multiple lymphomatous polyposis lp is a rare entity, characterized by multiple polypoid tu mors involving several segments of the gastrointestinal tract.
Pathology outlines mantle cell lymphoma, classic variant. Multiple lymphomatous polyposis mlp is uncommon and is regarded as the intestinal form of mcl. Multiple lymphomatous polyposis of the gastrointestinal tract. Alkpositive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis. We report a rare case of multiple lymphomatous polyposis of the gastrointestinal tract in which the patient. The subsequent workup included a thoracoabdominopelvic computed tomography ct scan that revealed thickening of several segments of the small and large intestinal walls, most prominent in the terminal ileum, multiple mesenteric adenopathies and homogeneous hepatosplenomegaly. Pdf multiple lymphomatous polyposis of the gastrointestinal. Lymphomatous definition of lymphomatous by medical dictionary. Multiple lymphomatous polyposis of the colon and rectum. A rare presentation of multiple lymphomatous polyposis with. Sep 10, 2014 the ileocecal region is the commonest site involved. Multiple lymphomatous polyposis financial definition of. A unique presentation of primary intestinal malt lymphoma as.
Multiple lymphomatous polyposis form is common but not specific for mantle cell lymphoma in the gastrointestinal tract. We present a typical case diagnosed by using an intestinal barium followthrough and ct scan which revealed gastric, ileac and colonic involvement as well as retroperitoneal. Multiple lymphomatous polyposis mlp is a distinctive type of primary gastrointestinal lymphoma characterized by polypoid accumulations of lymphoma tissue involving long segments of the gastrointestinal tract. Primary gastrointestinal tcell lymphoma resembling. Despite prompt remission, prognosis remains poor in view of increased relapse rates. Saito m, izumiyama k, ogasawara r, mori a, kondo t, tanaka m, morioka m, miyashita k, tanino m. The condition has a characteristic pathological appearance and immunophenotype which is important in allowing distinction from other less aggressive forms of gastrointestinal. We report a rare case of multiple lymphomatous polyposis of the gastrointestinal tract in which the patient presented with abdominal pain and bloody diarrhea. A unique presentation of primary intestinal malt lymphoma. Multiple lymphomatous polyposis mlp is a type of manifestation of mantle cell lymphoma mcl and it is characterized by multiple polypoid lesions involving long segments of the gastrointestinal tract and it accounts for only approximately 12% of non hodgkin lymphomas.
Primary nonhodgkins lymphoma nhl of the gastrointestinal gi tract is the most common extranodal nhl and accounts for 4%20% of all nhl. A rare case of multiple lymphomatous polyposis with. In addition, immunohistochemical analysis of the biopsy tissues demonstrated positive staining for cd20, cd5, bcl 2, cd43 and mantle cell lymphoma with multiple lymphomatous polyposis and intussusception. It is characterized by multiple polypoid lesions involving long gastrointestinal tracts and it accounts for only approximately 12% of nonhodgkin lymphomas. Sep 16, 20 the gastrointestinal tract is the predominant site of appearance of extranodal nonhodgkin lymphomas. Multiple lymphomatous polyposis and the role of fine. Asymptomatic multiple lymphomatous polyposis identified during. A study of four cases of mlp has shown a tendency for ileocaecal involvement and extra. Multiple polypoid masses of the distal ileum were identified in the right hemicolectomy specimen multiple lymphomatous polyposis.
Multiple lymphomatous polyposis is a rare form of gastrointestinal lymphoma characterized by the presence of multiple polyps throughout the length of the digestive tract. Multiple intestinal lymphomatous polyposis in a jindo dog. Multiple lymphomatous polyposis of the gastrointestinal tract scielo. Multiple lymphomatous polyposis mlp is an uncommon type of primary nonhodgkin gastrointestinal gi bcell lymphoma characterized by the presence of multiple polyps along the gi tract. In this large retrospective series of 12 pa tients with lp, histologic and immunohistochemical fea tures were investigated from patients with multiple bi.
It is characterized by a particular involvement of the gastrointestinal tract in which long segments are the location of numerous. There was no particular history except an episode of upper gi ugi bleeding 25 years ago. Histologically, benign lymphoid hyperplasia is the entity most likely to be confused with lymphomatous polyposis. Multiple lymphomatous polyposis mlp is thought to be a typical form of gastrointestinal lesion in mantle cell lymphoma, but it develops in other bcell lymphomas. Clinical symptoms may closely resemble those of colorectal carcinoma and diagnostic confusion may result. Multiple lymphomatous polyposis mlp as an extranodal manifestation of mantle cell lymphoma mcl in the.
The gastrointestinal tract is the predominant site of extranodal nonhodgkin lymphomas. Malignant cells of mlp have mantle cell characteristics and thus are considered to be the counterpart of the mantle cell lymphoma mcl in the gi tract. Both patients had multiple polypoidal defects involving large segments of gastrointestinal tract. Multiple lymphomatous polyposis overexpressing cyclin d1. As primary tumor, malignant lymphoma accounts for 0. A second colonoscopic examination performed in july 2004 revealed increased numbers of polyps, indicating a case of multiple lymphomatous polyposis mlp. Multiple lymphomatous polyposis of the intestine with ileocecal. Multiple lymphomatous polyposis may also be seen in marginal b cell lymphomas, mucosa associated lymphoid tissue malt, and follicular lymphomas. A 60yearold woman with known chronic lymphocytic leukemia cll had an exophytic mass of the appendiceal orifice. Endoscopic mucosal resections were performed on lesions and the resected specimens suggested mantle cell lymphoma mcl. Multiple lymphomatous polyposis of the gastrointestinal tract article pdf available in sao paulo medical journal 1223. The histopathology in both cases was diffuse poorly differentiated lymphoma.
Extensive colorectal lymphomatous polyposis complicated by acute. The aim of this study was to analyze the clinicopathologic features and outcome of a large series of patients. Mantlecell lymphoma multiple lymphomatous polyposis of the entire gi tract a 65yearold white man was admitted at to the emergency room with melena of moderate severity in may 2005. We report an unusual case of a patient with multiple. Clinical features, family history, and histology usually distinguish these conditions.
Multiple lymphomatous polyposis is considered to be a rare condition, with most of the cases being extranodal counterpart of mantle cell lymphomas. Sep 22, 2016 multiple lymphomatous polyposis mlp is uncommon and is regarded as the intestinal form of mcl. He received daily 100 mg of aspirin, enalapril maleate. A 78 years old patient was admitted to our department of general surgery with rectal bleeding, abdominal pain and weight loss. The commonest gastrointestinal gi manifestation is multiple lymphomatous polyposis, in which multiple lymphoid polyps are present in the gi. A patient with this condition who achieved a complete remission with combination chemotherapy is reported. This rare entity has been recently reclassified as mantle cell lymphoma. Gastrointestinal multiple lymphomatous polyposis is a rare type of malignant lymphoma that has aggressive biological behavior, early systemic. Multiple lymphomatous polyposis definition of multiple.
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